Among the most important aspects of your pet’s preventive health care program involves the use of medications that safeguard against parasites. A trusted choice employed by veterinarians for many years, fenbendazole is the most effective anthelmintic (parasite medication) available to dogs and cats. Typically administered orally, fenbendazole eliminates roundworms (Toxocara canis, Toxascaris leonina), hookworms (Ancylostoma caninum, Uncinaria stenocephala), whipworms (Trichuris vulpis) and tapeworms such as Taenia pisiformis and giardiasis. Fenbendazole is also one of the anthelmintics that have been shown to have activity against trematodes that can cause gastrointestinal disease in people (Heterobilharzia spp., Nanophyetus salmincola and Platynosomum fastosum).
While not FDA approved for veterinary use, fenbendazole is readily utilized in the veterinary field and is often prescribed off-label, or out of its normal labeling, when other options are unavailable or when fresh research proves it to be effective. This practice is known as extra-label prescribing and is legal in most states.
When ingested orally, fenbendazole is excreted within 48 hours. For this reason, a course of treatment requires several days in a row to ensure that the parasites are eliminated from the body. Occasionally, this medication may have side effects such as stomach pain or diarrhea in humans who take high doses or long durations of this drug. This is especially common for those with liver failure or abnormalities as this condition can reduce the amount of drug that is excreted.
Considering the similarity in the chemical structure of fenbendazole to nitroheterocyclic cytotoxins and radiosensitizers, we tested its effect on tumor growth by comparing fenbendazole treated EMT6 cells with non-treated controls. Treatment with 10 mM fenbendazole before and during irradiation did not alter radiation dose-response curves for aerobic or hypoxic EMT6 cells. fenbendazole capsules