The anecdotal claim that fenbendazole, a dog deworming medicine, cures cancer has gained traction on social media. This is largely due to a video series by unlicensed veterinarian Andrew Jones that has received millions of views on Facebook and TikTok. In the videos, Jones tells of his client who says he was diagnosed with lung cancer and cured by taking fenbendazole. He also claims the drug has been shown to work in lab tests. In reality, there is no evidence that fenbendazole can cure cancer in humans, and if anything it may actually hurt.
The benzimidazole antihelmintic agent fenbendazole is known to bind beta-tubulin and disrupt microtubules, causing cell cycle arrest and inducing apoptosis . It has been shown that the cytotoxic effect of fenbendazole on cancer cells is primarily caused by the induction of G2/M phase checkpoint activation, as well as p53-p21-dependent apoptosis and autophagy, and that it inhibits cell proliferation and growth in 5-FU-sensitive colorectal cancer (CRC) cell lines.
In addition to these effects, fenbendazole has been shown to induce RAS-related signaling pathway suppression in CRC cells with a KRAS mutation. It has also been shown to have a broad range of cytotoxic activities in other tumor models.
These cellular mechanisms of action are not unique to fenbendazole, and they are similar to those of other drugs already approved for use in humans during randomized clinical trials. For example, paclitaxel and vincristine act in the same way as fenbendazole to cause cancer cell death.
Studies have shown that fenbendazole can reduce tumor growth in human fibrosarcoma cells in vitro, but they don’t show that it works as a treatment for cancer in people. In a case study, an anecdotal account by a man named Joe Tippens went viral online after he claimed that fenbendazole “cured” his cancer. But there is no evidence that fenbendazole does what he claims, and the cancer treatments he received probably played a larger role than fenbendazole.
It’s possible that fenbendazole could help to treat some types of cancer in certain patients, but more research is needed. The U.S. Food and Drug Administration told Full Fact that fenbendazole hasn’t been proven to be effective in treating cancer in humans, so it’s important to stick with conventional treatments that have been tested in randomized clinical trials. The nonprofit organization Cancer Research UK told Full Fact that although the anecdotal evidence gathered from Tippens’ case is interesting, it isn’t enough to prove that fenbendazole can prevent or cure cancer. In order to do so, randomized clinical trials must be conducted in large numbers of people. fenbendazole for cancer