Peptide Nasal Sprays
The nasal delivery route is a promising route for delivering therapeutic proteins and peptides to the CNS. The N-to-B route via the nasal mucosa bypasses the blood-brain barrier and may be less immunogenic than other systemic routes. However, most of the published studies of peptides and proteins delivered to the brain by nasal administration use liquid formulations like emulsions, suspensions, and sprays [103]. A dry powder spray is an alternative that has been shown to be more effective than liquid sprays in delivering drug to the brain.
Phylomer peptides are ideal candidates for a nasal spray due to their small size and high solubility. A recent study [108] using the Phylomer Intravail platform showed that a dry powder spray of a synthetic A1R-CT peptide was superior to the same peptide delivered by a commercial liquid nasal spray and sublingual tablet in terms of CSF peptide concentrations, with higher medication stability, lack of preservatives and propellants, and fewer side effects.
This peptide works by inhibiting the protein neurabin, which provides balance to the hyperactivity of the A1 receptor and prevents excessive electrical activity that causes seizures. Inhibiting neurabin with their peptide enabled increased action by A1C and reduced the excessive electrical activity that causes seizures in both an Alzheimer’s mouse model and a severe seizure mouse model.
It’s important to note that peptide therapy should only be administered under the guidance of a trained healthcare professional. Peptide therapy is not a replacement for proper medical care, but an additional supplement to help you feel your best! peptide nasal sprays